For a patient prescribed digoxin IV 0.375 mg and the available vial concentration is 0.25 mg/mL, how many milliliters should be administered?

For a patient prescribed digoxin IV 0.375 mg and the available vial concentration is 0.25 mg/mL, how many milliliters should be administered?

• A. 1.0 mL
• B. 1.25 mL
• C. 1.5 mL
• D. 1.75 mL

Answer: (C)

When converting a prescribed drug amount to the administration volume, use volume = dose ÷ concentration. For this digoxin order, the dose is 0.375 mg and the vial concentration is 0.25 mg/mL. So the volume to give is 0.375 mg ÷ 0.25 mg/mL = 1.5 mL. Therefore, administer 1.5 mL IV. Remember, digoxin has a narrow therapeutic range, so always double-check the calculation against the order and concentration before administration.

When converting a prescribed drug amount to the administration volume, use volume = dose ÷ concentration. For this digoxin order, the dose is 0.375 mg and the vial concentration is 0.25 mg/mL. So the volume to give is 0.375 mg ÷ 0.25 mg/mL = 1.5 mL. Therefore, administer 1.5 mL IV. Remember, digoxin has a narrow therapeutic range, so always double-check the calculation against the order and concentration before administration.